Innoko National Wildlife Refuge is a roadless, relatively flat plain containing most of the Innoko River drainage and bordered on the west by the Yukon River.
About 80 percent of the refuge is wetlands; there are innumerable small lakes, streams, and bogs that are enriched by annual flooding associated with river runoff. Moose, wolves, waterfowl, and bears are common. Salmon, sheefish, and northern pike abound in refuge streams and lakes. The refuge contains several abandoned towns, remnants of the gold rush era, but no occupied communities. Residents of fifteen villages hunt and fish on the refuge for subsistence. The high moose population attracts many hunters in the fall. Other visitors float refuge rivers, fish and explore historical sites.