Denison is located in Grayson County north of Dallas between Sherman and the Oklahoma State line along US 75 on the banks of the Red River near Lake Texoma.
Denison was the birthplace of the thirty-fourth president of the United States, Dwight David Eisenhower. The home he was born in in 1890 has been returned to its original appearance and sits in the Eisenhower Birthplace State Historic Site, a three-acre area that includes a museum.
The population estimate for July 1, 1998 was 22,170, an increase of 665 since 1990.
Denison is part of the Sherman-Denison, Texas metro area.