Winters is located in Runnels County south of Abilene toward Ballinger along Hwy 83, Farm roads 1770 and 53, and the Missouri-Pacific Railroad.
The population was 600 in 1909, when the Texas and Pacific Railway built an extension to Winters from Abilene. The first major industry was a cottonseed oil mill established in 1909, the year the town was incorporated. The plant closed in 1939. A public library was built in 1964 and improved in 1968. Manufactured items include air conditioning equipment, metals, lenses, outdoor lighted signs, and aircraft parts.
Annual events include a show sponsored by the West Texas Shetland Pony Breeders Association.
The 1980 population of 3,061 was a little more than double that in 1910 at 1,247. In 1970 Winters had ninety-six businesses. In 1990 the population was 2,905.